Oxybutynin is an internationl name of active substance Oxybutynin chloride, coming into the retail market under different trade names. In the USA, Oxybutynin medication is sold under trade names: Ditropan; Ditropan XL; Gelnique; Anturol and Oxytrol.
Indications for Oxybutynin use
- Oxybutynin medication is appointed adults and children with unstable bladder function (overactive bladder), the main symptom of which is urinary incontinence.
- In urinary incontinence and treatment of nocturnal enuresis in children, the use of Oxybutynin medication is contraindicated in children under 5 years old.
Mechanism of pharmacological action Oxybutynin medication
Oxybutynin medication has spasmolytic and anticholinergic effect on muscle tissue (detrusor) which reduces the bladder, thus Oxybutynin:
- reduces the frequency of detrusor contractions;
- restrains the urges to frequent urination (incontinence);
- reduces the frequency of voluntary urination episodes;
- increases the capacity of the bladder.
Recommended dosing regimen of Oxybutynin medication
Oxybutynin tablets are recommended to take on an empty stomach, an hour before or 2 hours after food.
For adults:
- Average daily dose of Oxybutynin is 15 mg (1 tablet of Oxybutynin 5 mg – 3 times a day).
- Maximum daily dose of Oxybutynin is 20 mg (1 tablet of Oxybutynin 5 mg – 4 times a day).
- In the case of frequent episodes of nocturnal enuresis (in adherence of the recommended dosing regimen) the patient can be advised to use one tablet of Oxybutynin 15 mg, just before bedtime.
For elderly:
- It is recommended to start with the minimum daily dose – Oxybutynin 7,5 mg (½ tablets Oxybutynin 5 mg – 3 times a day).
For children over 5 years and adolescents:
- Treatment course is recommended to start with the minimum daily dose – Oxybutynin 10mg (1 tablet of Oxybutynin 5mg – 2 times a day).
- If needed, the daily dose can be increased up to 15 mg (1 tablet of Oxybutynin 5 mg – 3 times a day).
Daily dose of Oxybutynin should be increased gradually, not more than 1 tablet of Oxybutynin 5 mg every 7 days.
Contraindications to Oxybutynin tablets use
Oxybutynin tablets are contraindicated for patients with:
- gastrointestinal obstruction;
- uncontrolled glaucoma
- allergy to active substance Oxybutynin chloride
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